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September 30, 1899


JAMA. 1899;XXXIII(14):839-845. doi:10.1001/jama.1899.92450660029001i

Migraine and headache are commonly considered synonymous terms. Migraine is, however, a distinct disease, the headache being its most pronounced and distressing symptom. In rare cases we may even have migraine without headache. It is undoubtedly the most frequent of all neuroses.

It is my desire to record some of the more striking manifestations of the disease as gathered from an unusually rich clinical experience. I shall base my remarks on the notes taken on fifty consecutive cases, the majority of which are taken from the neurologic clinics of Dr. H. T. Patrick, Chicago.

In looking over the notes, the first important item is the family history, the usual entry being "mother migrainous," "mother and two maternal aunts migrainous," "mother and mother's mother migrainous," "mother and father migrainous," "mother and two sisters migrainous," etc., the disease showing itself in six or seven members of a family in some instances. To