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Article
September 30, 1899

THE ORIGIN AND OCCURRENCE OF EOSINOPHILOUS CELLS IN THE SPUTUM.

JAMA. 1899;XXXIII(14):864-865. doi:10.1001/jama.1899.02450660054006
Abstract

One of the most conspicuous elements in the richly-colored blood preparation, made according to Ehrlich's method, is the eosinophilous cell. The brilliantly stained granules in its protoplasm make this cell a marked object. Nevertheless, but very little is known concerning the place and the mode of its origin; the opinions of the investigators on these points vary greatly. The occurrence of eosinophilous cells in the sputum, under various conditions, has also attracted considerable attention. Their presence in the sputum is explained in two directly contradictory ways: Ehrlich and others derive them from the blood; but their presence in the sputum in enormous numbers in bronchitis and bronchial asthma without a corresponding eosinophilia in the blood has given rise to the opinion that they are formed in the respiratory tract. Fuchs1 recently called attention to the possibility that eosinophile cells and free granules in the sputum might in some cases

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