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November 4, 1899


JAMA. 1899;XXXIII(19):1171-1172. doi:10.1001/jama.1899.02450710053006

The mechanism of the production of substances which are antagonistic to the harmful action of bacteria is being actively studied. We already know of a considerable number of so-called antibodies which are produced in the body under the influence of various stimuli. There are antitoxins, the agglutinins, the various anti-hematic substances, the lactoserum which precipitates milk, etc. Ladislas Deutsch studies the origin of the antibodies in typhoid infection1. A single intraperitoneal injection of a culture of the typhoid bacillus into a guinea-pig is followed by the production of antibodies. The antityphoid power of the serum appears on the fourth to the fifth day, and reaches its maximum on the eleventh or twelfth, when 0.05 c.c. protects against twice the fatal dose. This property then rapidly diminishes and disappears wholly in one month. The antityphoid substance or substances are present to a slight extent in the liver, the kidneys, the adrenals