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Article
November 25, 1899

GASTRIC ULCERS IN THE COURSE OF PNEUMOCOCCUS SEPTICEMIA IN THE GUINEA-PIG.

JAMA. 1899;XXXIII(22):1366. doi:10.1001/jama.1899.02450740054011
Abstract

The experimental lesions caused by the pneumococcus may present a fibrinous and hemorrhagic type, the latter being the result of the most virulent form of the microbe. In the rabbit, for instance, successive inoculations produce in the beginning a fibrinous reaction, later, when the microbes have passed through several animals, a hemorrhagic reaction. The same may be brought about in. the guinea-pig, which is a refractory animal as regards the pneumococcus. The hemorrhagic lesions of the pneumococcus infection in the rabbit are observed especially in the suprarenal capsules, genital organs, the surface of the large intestine, and in some cases the wall of the stomach. When the ecchymoses in the stomach are situated in the mucous membrane, the action of the gastric juice rapidly transforms the small hemorrhagic areas into ulcers. This was demonstrated in three cases by Bezancon and Griffon1. The microscopic examination of the ulcers shows that

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