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December 2, 1899


JAMA. 1899;XXXIII(23):1439. doi:10.1001/jama.1899.02450750059027

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SERUM THERAPY IN CANADA IN THE SIXTIES.  Sir James Grant of Ottawa can probably justly be considered as a pioneer of serum therapy. Long before Robert Koch demonstrated the tubercle bacillus in the sputum of the subjects of phthisis pulmonalis—even as far back as 1863—Dr. Grant had published in the London Medical Times and Gazette a series of cases treated by him demonstrating the possibility of the ordinary vaccin acting as a curative remedy, a sort of alterative on the nutrition in certain skin diseases and contagious affections. Case 1 was of psoriasis palmaris, which, occurring in a man of 25 years, strong and robust, baffled ordinary treatment for five years. Vaccination was performed, and as the pustule advanced in formation from the third to the seventeenth day, it was noticed that the disease on the hands and fingers gradually progressed favorably until the twentieth day, the parts had regained

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