The different opinions in regard to mixed infection in pulmonary tuberculosis and phthisis may be summarized under the following heads: 1. Mixed infection is without any special influence on the phthisical processes— etiologic unity (v. Leyden, Strauss, Frankel and others). 2. Phthisis is always the result of mixed infection—etiologic duality (Maragliano and others). 3. Severe manifestations of phthisis are always and wholly, or at least in part, the result of mixed infection (Koch, Ziegler, Weichselbaum, and others). Sata1 has made careful bacteriologic and histologic examinations of a number— twenty-one—of suitable cases, in nearly all of which the clinical symptoms had been recorded, in order to establish to what extent the exudative and necrobiotic processes are modified by mixed infection, in what stage of pulmonary tuberculosis it usually sets in, if at all, and to what degree tubercle bacilli only may cause phthisical phenomena. Twelve cases of pronounced mixed infection
MIXED INFECTION IN PULMONARY TUBERCULOSIS. JAMA. 1899;XXXIII(26):1619–1620. doi:10.1001/jama.1899.02450780051007
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