From Römer's3 experimental studies of infection from the conjunctival sac, we learn that in the case of the rabbit and the guinea-pig, the conjunctival sac is an extremely dangerous route of general infection, as dangerous as, if not more than, any and all other recognized routes; it is not necessary to produce any preliminary injury to the tissues, severe general infection may result from the introduction of microbes into the intact conjunctival sac, and in a large percentage of such cases the resulting septicemias progress more rapidly than when the germs are introduced into the subcutaneous tissue. The germs do not enter the general circulation by way of the conjunctiva itself; it remains protected by its anatomic structure and by being constantly bathed with tears. The resorptive activities of the nasal mucous membrane play the principal part in the general infection; Römer demonstrates, by means of histologic sections, that
THE CONJUNCTIVAL SAC AS PORTAL OF INFECTION. JAMA. 1900;XXXIV(4):241. doi:10.1001/jama.1900.02460040051011
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