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February 17, 1900


JAMA. 1900;XXXIV(7):435. doi:10.1001/jama.1900.02460070051007

A final opinion has not yet been rendered as to the exact nature of the condition of transient hypertonia that develops after a period of rest in muscles put into activity, as described in detail by Thomsen and usually known by his name, and of which this observer is himself a conspicuous instance. In some cases the affected muscles have presented evidences of hypertrophy, although they are weak rather than strong. The motor end-plate appears to suffer particularly. The disease is not common, probably not many more than 100 cases having been placed on record. The etiology is obscure, although hereditary influences have been present in the majority of instances. Treatment has been unavailing, although Thomsen has thought that a life of muscular activity is capable of affording some relief. Gessler1 suggests, however, that the therapeutic indication is to neutralize the congenital muscular hypertrophy, and this can be done