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February 24, 1900


JAMA. 1900;XXXIV(8):455-458. doi:10.1001/jama.1900.24610080007001b

In the consideration of any phase of the typhoid fever question, we are confronted by, and must take cognizance of, the following facts: 1, that the disease is a general infection by a germ which circulates freely in the blood and may find lodgment, and cause inflammatory reaction in almost all organs and tissues of the body, and that it possesses pyogenetic properties; 2, that typhoid infection predisposes to the occurrence of secondary infection, especially by the pyogenic organisms, as the streptococcus, staphylococcus, and also by the pneumoeoccus, the bacterium coli and the bacillus of tuberculosis. Furthermore, there seems to be no uniformity in the use of the term, "complication." Is it to be employed in designating all the unusual manifestations of the affection when due to the typhoid bacillus alone, or only to those complications which follow secondary infection?

I shall, as far as possible, limit my remarks to

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