While the pathology of insanity in general is still in its infancy, yet the importance of vascular lesions of various kinds is fully recognized. These lesions may affect brain tissue in two ways: the supply of blood may be diminished or shut off and the return flow of lymph delayed. The retardation of the lymph current may result in mechanical injury to the nerve-cells, which are also exposed to the deleterious action of waste products in the lymph. Surely the bathing of nerve-cells in lymph laden with effete materials must be highly detrimental to normal function and structure. As pointed out by Berkeley in his recent article on the general pathology of mental diseases1, one of the most frequent causes of the retardation of the return of lymph lies in the proliferative changes in the adventitia whereby the perivascular spaces become filled with cells. The milky-gelatinous thickenings so common
PATHOLOGY OF THE CEREBRAL VESSELS. ESPECIALLY IN RELATION TO MENTAL DISEASES. JAMA. 1900;XXXIV(8):499–500. doi:10.1001/jama.1900.02460080051007
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