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Article
February 24, 1900

BONE CHANGES IN INFANTILE SCURVY (BARLOW'S DISEASE).

JAMA. 1900;XXXIV(8):500-501. doi:10.1001/jama.1900.02460080052011
Abstract

The real nature of the changes underlying the abnormal conditions of the osseous system in infantile scurvy has not been fully cleared up. In a comparatively rare disease like this considerable time must needs pass by before enough material of a suitable character can accumulate so that the pathologic anatomy can be studied in the various stages of its evolution. In a case of infantile scurvy recently studied post-mortem, by Jacobsthal,1 the gross examination showed: suggillations of the skin; small hemorrhages in the pleura, pericardium, lungs, muscles, periosteum, joints and bone marrow, cranial, periosteal, endosteal, and perichondral osteophytes; epiphysiolysis in the femurs and the left tibia; atrophy of muscles and bones. The most striking feature is the marked hemorrhagic diathesis giving rise to the characteristic subperiosteal hemorrhages. As a result of the hemorrhagic tendency, the cause of which is as yet unknown, hemorrhages occur especially in those parts that

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