In the treatment of syphilis it is sometimes desirable to bring the system speedily under the influence of mercury. This might be accomplished by means of subcutaneous injections, but for a number of reasons this method has not come into general employ. As large doses of mercury administered by the mouth are generally not well borne, and as absorption from the gastrointestinal tract is relatively slow, this route will not be employed when speedy physiologic results are acquired. The introduction of mercury through the skin by sublimation has never been popular, and is at present but little if at all employed. Inunction, however, appears to be one of the most efficacious and trustworthy, as well as simple and practicable modes of administering mercury. Kutner2 expresses the opinion that when this is applied to the skin it is not absorbed, as it has been shown that it is not present
TREATMENT OF SYPHILIS BY INHALATIONS OF MERCURIAL VAPOR. JAMA. 1900;XXXIV(8):502. doi:10.1001/jama.1900.02460080054015
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