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There would seem to be no obvious reason why inflammation of the urethral mucous membrane should be exclusively dependent on the invasion and pernicious activity of gonococci. Lesions of other mucous membranes are not so restricted in etiology, and it may be reasonably believed that the urethra shares in this susceptibility to the action of a multiplicity of irritants. Existing evidence, however, as to the occurrence of a non-gonorrheal urethritis, while not deficient in amount, lacks somewhat in the precision necessary for scientific demonstration. The difficulties to be overcome consist in the exclusion of gonorrheal infection, recent or remote, of syphilis, of tuberculosis, of chancroid, of herpes and of other irritative conditions of the urethra. On the assumption that urethritis may arise independently of gonorrhea, the following classification has been suggested—1. Urethritis due to internal causes: a, constitutional disease; b, ingested substances. 2. That due to external causes; a, traumatism;
NON-GONORRHEAL URETHRITI S. JAMA. 1900;XXXIV(8):502–503. doi:10.1001/jama.1900.02460080054016
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