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Article
March 3, 1900

ACUTE NONSYPHILITIC MALIGNANT PEMPHIGUS OF THE NEWBORN.

JAMA. 1900;XXXIV(9):565. doi:10.1001/jama.1900.02460090051011
Abstract

Bloch1 reports a group of cases of acute non-syphilitic pemphigus of the newborn, and expresses the opinion that this disease may appear in two forms, a benign and a malignant The latter variety, which terminates fatally in the majority of cases, depends on septicemic infection, the streptococcus pyogenes being the exciting factor, although the portal of infection is not obvious. From a differential diagnostic point of view extensive scalds, foliaceous pemphigus and exfoliative dermatitis must be taken into consideration. Many cases of malignant pemphigus are erroneously described as instances of foliaceous pemphigus. Many cases of so-called exfoliative dermatitis are really instances of acute malignant pemphigus of the newborn. Pemphigus can by no means be considered as one of the innocent diseases of infancy. Its great transmissibility, particularly through midwives, should require legal notification. In treatment, ointments—1 per cent. salicylated ointment—may be employed in the benign cases. In the malignant

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