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March 3, 1900


JAMA. 1900;XXXIV(9):568. doi:10.1001/jama.1900.02460090054023

This portentous name was originally devised for a condition observed in apparently healthy horses, and characterized by interference with locomotion after a period of activity, in association with pain, tremor, and excessive perspiration. The symptoms disappear after a period of rest, but recur under the conditions named. The disorder was found to depend on obstruction of the blood-vessels supplying the affected members. Subsequently a similar disturbance was found in man, and it presented the same pathologic lesions. It is, however, not confined to the hind legs in horses, or the inferior extremities in man. On post-mortem examination arteriosclerosis seems to be the essential underlying factor, and the etiologic elements include all of those influences capable of causing degenerative changes in the blood-vessels. The disorder must be differentiated from sciatic neuritis, alcoholic neuritis, tabes dorsalis, multiple sclerosis, rheumatism, and Raynaud's disease. To the small number of cases recorded Grassman1 adds