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May 5, 1900


JAMA. 1900;XXXIV(18):1134. doi:10.1001/jama.1900.02460180046007

Pain may arise from irritative disturbance at any point in the course of a sensory nerve between the cerebral cortex and the periphery, and the exciting cause may be of most varied character—inflammatory, degenerative, toxic, organic, structural. The treatment must necessarily vary accordingly. To functional disturbances we shall make no reference further than to express the opinion that derangement of function always depends on, or at least is associated with, physical alteration of structure, although this may be of such an impalpable nature as to be beyond our present powers of observation. It is probable that under these conditions the alterations that take place may be looked upon as of a nutritional, chemical or toxic origin. These considerations are of importance in connection with the treatment of the group of disorders known as neuralgias, and than which no more painful affection exists.

At the recent joint meeting of the College