In order to understand the peculiar and complicated developmental cycles of the malarial parasites, it is necessary to consider the organisms most closely related to them, namely the coccidia, because the details concerning these are much better known. As there is no change of host in the case of the coccidia, the process is not so complicated as in the malarial parasites. Shorn of a wealth of detail, the developmental cycle of the coccidia runs somewhat as follows, according to the recent review, by Lühe,1 of the investigations of sporozoa, with especial reference to the malaria parasites and related organisms. As is well known, coccidia are found rather frequently in the intestinal tract and the liver of vertebrate and other animals. Examining the feces of an infected rabbit, for instance, there are found encysted parasites of varying size, which Schaudinn and other prominent investigators in this line call
THE DEVELOPMENTAL CYCLES OF THE ORGANISM OF MALARIA.. JAMA. 1900;XXXIV(21):1345–1346. doi:10.1001/jama.1900.02460210051007
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