Nucleated red corpuscles were first found in the blood in cases of leukemia, after death, and subsequently also in the circulating blood. In other instances, however, they could not be demonstrated. Their presence was at one time believed to be indicative of medullary leukemia, and attributed to abnormal activity of the bonemarrow. As experience increased nucleated red corpuscles were found also in the blood in cases of pernicious anemia, and even in cases of secondary anemia, of varying intensity. It was then demonstrated experimentally that nucleated red blood-corpuscles occur in all diseases attended with rapid disorganization of the blood, and their presence must be looked on as indicating insufficiency of the blood-generating organs, which become incapable of neutralizing the increased loss with normal red cells. The presence of megaloblasts, with or without nuclei, bespeaks grave disturbance in hemogenesis. The explanation of the anemia secondary to leukemia is not clear. It
PRESENCE OF NUCLEATED RED CORPUSCLES IN THE CIRCULATING BLOOD IN MAN. JAMA. 1900;XXXIV(24):1564–1565. doi:10.1001/jama.1900.02460240056008
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