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June 16, 1900


JAMA. 1900;XXXIV(24):1569. doi:10.1001/jama.1900.02460240061018

The etiology of cirrhosis of the liver still presents many obscure points. Investigators have endeavored to experimentally, produce cirrhosis of the liver in animals, but so far the success has been rather indifferent. It is true that certain chemical and toxic substances have been found to induce cirrhotic processes in the livers of animals, but it does not seem that any method has yet been devised that will reproduce at will, in any degree of completeness, the various changes observed in human cirrhosis. Injurious agents that act acutely and severely on the liver do not necessarily result in consecutive connective-tissue proliferation, because the liver has power in a high degree to regenerate after necrosis and degeneration. The general opinion is that cirrhosis develops from the action of substances that operate in a chronic manner and in some way induce the growth of fibrous tissue. The peculiarities of the tissues of