In order to obtain some idea as to the part played by trauma in the development of tumors, v. Bunger proposed that a collective investigation be instituted to cover the years 1893-1898. In response, Wurz1 presents a study of the cases of tumor that were treated at v. Brun's clinic during this time. The material includes 584 malignant and 129 benign, in all 713 tumors. The relation of trauma to these tumors was studied critically, such factors as chronic irritation, scars, etc., being excluded. The principal forms of trauma studied consequently are contusions and small solutions of continuity of various kinds. Of the benign tumors, osteomata afforded the most striking examples of the action of trauma, the tumor beginning to develop as soon as eight to fourteen days after the injury. An instance is cited in which adenoma of the breast began immediately after an injury. On the whole,
INFLUENCE OF TRAUMA ON THE DEVELOPMENT OF TUMORS. JAMA. 1900;XXXIV(25):1635–1636. doi:10.1001/jama.1900.02460250047010
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