Antibiotic treatment of infants and young children with acute otitis media at diagnosis is superior to taking a watchful waiting approach, according to findings from 2 placebo-controlled trials (Hoberman A et al. N Engl J Med. 2011;364:105-115 and Tahtinen PA et al. N Engl J Med. 2011;364:116-126).
Two independent teams in Pittsburgh and Finland randomized 600 children who had a definitive diagnosis of otitis media to receive either amoxicillin-clavulanate or placebo. In both trials, antibiotic therapy was associated with a faster recovery and a lower rate of clinical failure compared with placebo use.
Friedrich MJ. Antibiotics for Otitis Media. JAMA. 2011;305(7):663. doi:10.1001/jama.2011.136
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