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March 16, 2011

Performance of Immunochemical Fecal Occult Blood Tests Among Users of Low-Dose Aspirin

JAMA. 2011;305(11):1093-1094. doi:10.1001/jama.2011.297

To the Editor: Dr Brenner and colleagues reported in a recent study1 on the relationship between low-dose aspirin use and performance of immunochemical fecal occult blood tests as screening tools for colorectal cancer (CRC). The authors proposed, based on the findings, that low-dose aspirin may be used to improve the performance of fecal occult blood tests. We are concerned that the study methods were based on the assumption that neither chronic aspirin use nor underlying conditions associated with its use would alter the risk of CRC.