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June 22 2011

Standard- vs High-Dose Clopidogrel After Percutaneous Coronary Intervention

Author Affiliations

Author Affiliations: Division of Cardiology (Dr Jeong) (goodoctor@naver.com) and Department of Laboratory Medicine (Drs Park and Kim), Gyeongsang National University Hospital, Jinju, Korea.

JAMA. 2011;305(24):2520-2522. doi:10.1001/jama.2011.842

To the Editor: The results of the Gauging Responsiveness with a VerifyNow assay–Impact on Thrombosis and Safety (GRAVITAS)1 and Clopidogrel and Aspirin Optimal Dose Usage to Reduce Recurrent Events–Seventh Organization to Assess Strategies in Ischemic Syndromes (CURRENT-OASIS 7)2 trials suggested that high-dose clopidogrel after percutaneous coronary intervention (PCI) can exhibit different clinical efficacy according to the study design. CURRENT-OASIS 7 found a reduction in cardiovascular death, myocardial infarction (MI), or stroke at 1 month with double-dose clopidogrel (adjusted hazard ratio [HR], 0.86) while GRAVITAS, after 6 months, did not (HR, 1.01).