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January 11, 1965

Serum Globulin Dyscrasia: Lack of Virus Neutralizing Antibodies in Normal Serum and Hypergammaglobulinemia

Author Affiliations

From the Division of Microbiology, Department of Laboratories, Henry Ford Hospital, Detroit.

JAMA. 1965;191(2):97-102. doi:10.1001/jama.1965.03080020025007

The "immune-globulins" in human serum consist of three well defined and characterized classes; namely; 7S-γ2 (gamma-ss); 7S-γ11A, β2A) and 19S-γ1 (γ-1M, β2M). These plasma components are associated with antibody activity of major biologic importance to immunity and resistance. Since the advent of electrophoretic mobility studies, much has been published by Bruton,1,2 Janeway,3 Gitlin,4,5 Good,6 and their associates on the globulin deficiency syndrome. The classification of the deficiencies by agamma-, hypogamma-, and dysgamma-globulinemia has been most helpful in clinical medicine to explain certain abnormalities in humoral and cytological aspects of immunity. Although the electrophoretic mobility studies are most valuable in this respect, the practical information obtained by this procedure is of limited value concerning the three major immune globulins since these fractions cannot be completely separated by paper or cellulose acetate electrophoresis. The quantity of γ1-globulin