The "immune-globulins" in human serum consist of three well defined and characterized classes; namely; 7S-γ2 (gamma-ss); 7S-γ1 (γ1A, β2A) and 19S-γ1 (γ-1M, β2M). These plasma components are associated with antibody activity of major biologic importance to immunity and resistance. Since the advent of electrophoretic mobility studies, much has been published by Bruton,1,2 Janeway,3 Gitlin,4,5 Good,6 and their associates on the globulin deficiency syndrome. The classification of the deficiencies by agamma-, hypogamma-, and dysgamma-globulinemia has been most helpful in clinical medicine to explain certain abnormalities in humoral and cytological aspects of immunity. Although the electrophoretic mobility studies are most valuable in this respect, the practical information obtained by this procedure is of limited value concerning the three major immune globulins since these fractions cannot be completely separated by paper or cellulose acetate electrophoresis. The quantity of γ1-globulin
LoGrippo GA, Wolfram BR, Hayashi H. Serum Globulin Dyscrasia: Lack of Virus Neutralizing Antibodies in Normal Serum and Hypergammaglobulinemia. JAMA. 1965;191(2):97–102. doi:10.1001/jama.1965.03080020025007
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