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January 11, 1965

Effect of Various Hormones, Isotopes, and Isotope-Tagged Hormones on Breast Cancer in Rats

JAMA. 1965;191(2):116-118. doi:10.1001/jama.1965.03080020044013

Since the discovery that iodine 131 would concentrate selectively in the thyroid, scientists have searched for other radioisotopes which have a predilection for a particular tissue or organ. Unfortunately no other isotopes have been found that have the capacity to localize as dramatically as iodine does in the thyroid, and it is only recently that we have recognized the concept of attaching an isotope to a particular compound or substance which will be concentrated selectively at a specific site in a biological system. It is the purpose of these studies to explore the possibility of utilizing these concepts in the diagnosis and treatment of hormone sensitive neoplasms.

At the present time the diagnosis of hormone sensitivity of a given tumor can be established only by trial. At best, this results in a loss of time for the patient who might better be treated by some alternative method. At worst, the

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