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The alert physician has the occasional opportunity to diagnose Hodgkin's disease when it is clinically localized and potentially curable. In a large series of patients with this disease or in a busy practice, however, more than three fourths of the patients in whom Hodgkin's disease is histologically documented will have more disseminated disease. Discussion of the care of these patients will be restricted to those who have stage III or IV disease, that is, clinical evidence of widespread involvement by the tumor.
The physician must first recognize that he will require all of his skills as a physician, all of the warmth and human understanding which motivated him to become a doctor, in the care of the patient. Even though the patient may be in relatively good health when first seen with disseminated disease, it must be assumed that the course will be increasingly difficult for the patient, and his
Gellhorn A. Management With Chemotherapeutic Agents. JAMA. 1965;191(4):315–316. doi:10.1001/jama.1965.03080040057017
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