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January 25, 1965

Comment: Pregnancy and Childhood

JAMA. 1965;191(4):318. doi:10.1001/jama.1965.03080040060019

The management of advanced Hodgkin's disease has been well covered, however, in view of the younger age groups afflicted, the problems of care in pregnancy and childhood deserve mention. Conclusions reported in the literature remain controversial in regard to the influence of pregnancy on Hodgkin's disease. Early reports suggested that the Hodgkin's process was reactivated during pregnancy, but as more and more patients were encountered who survived, this opinion was challenged. The experience of Barry, Diamond, and Craver,7 based upon flow-sheet analysis of the exacerbations and remissions of the disease in 347 patients, of whom 84 became pregnant, provides us with some important answers. Active disease during both the first and second years of illness carried a grave prognosis in terms of morbidity and mortality. Therefore, they advise women against becoming pregnant in view of the prospect of repeated bouts of sickness despite good survival. The patient with a

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