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January 25, 1965

Generalized Reactions to Thyrotropin

JAMA. 1965;191(4):346-347. doi:10.1001/jama.1965.03080040088038

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To the Editor:—  I read with considerable interest the report of Drs. Sherman and Werner (JAMA190: 244 [Oct 19] 1964) of a generalized allergic reaction which occurred after the injection of bovine thyrotropin ( TSH). This case report emphasizes a complication which may be encountered when TSH is used on repeated occasions for radioactive iodine studies. In a previous publication (Mack, R.E., et al: Management of Thyroid Carcinoma, JAMA163:15 [Jan 5] 1957) the occurrence of a generalized reaction (vascular collapse, hives, and angioneurotic edema) after TSH injection in one of the illustrative cases (Case 1) is described. Reference is made in the text (p 19, Comment section) to a similar reaction which was encountered after administration of TSH in a patient with primary hypothyroidism. In neither of our cases was any attempt made to distinguish between TSH and the contaminating serum proteins as the offending antigen. Because of

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