An outbreak of a febrile disease, characterized by rash and arthritis, occurred in the Houston area in the spring of 1964. Rubella virus was isolated from the throat swabs obtained from seven of 28 patients, some of whom were considered clinically to have echovirus infections, and others to have arthritis. No other viral agent was isolated from feces and throat swabs of these patients in a variety of cell cultures used in this study. The virus was isolated by measuring its property of interfering with the growth of echovirus 11 in cultures of green monkey kidney. The Houston strain of rubella virus was observed in the electron microscope and found to resemble a paramyxovirus of marked pleomorphism.
Phillips CA, Behbehani AM, Johnson LW, Melnick JL. Isolation of Rubella Virus: An Epidemic Characterized by Rash and Arthritis. JAMA. 1965;191(8):615–618. doi:10.1001/jama.1965.03080080005001
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