In 17 additional cases of circumferential small-bowel ulcer, thiazide potassium chloride therapy seems implicated in the causation of the lesion. In patients receiving this therapy symptoms of postprandial crampy abdominal pain, occurring over a period of days, weeks, or months, should suggest the diagnosis. Perforation of such an ulcer should be suspected when such a patient has an acute condition within the abdomen. Careful x-ray studies may confirm the diagnosis preoperatively.
Morgenstern L, Freilich M, Panish JF. The Circumferential Small-Bowel Ulcer: Clinical Aspects in 17 Patients. JAMA. 1965;191(8):637–640. doi:10.1001/jama.1965.03080080027006
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