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February 22, 1965

The Circumferential Small-Bowel Ulcer: Clinical Aspects in 17 Patients

Author Affiliations

From the divisions of surgery, medicine, and laboratories, Cedars of Lebanon Hospital Division, Cedars-Sinai Hospitals, Los Angeles.

JAMA. 1965;191(8):637-640. doi:10.1001/jama.1965.03080080027006

In 17 additional cases of circumferential small-bowel ulcer, thiazide potassium chloride therapy seems implicated in the causation of the lesion. In patients receiving this therapy symptoms of postprandial crampy abdominal pain, occurring over a period of days, weeks, or months, should suggest the diagnosis. Perforation of such an ulcer should be suspected when such a patient has an acute condition within the abdomen. Careful x-ray studies may confirm the diagnosis preoperatively.