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March 1, 1965

Prisoners Play Important Role In Study of Respiratory Disease

JAMA. 1965;191(9):35-42. doi:10.1001/jama.1965.03080090109060

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Significant advances in immunization have resulted from testing respiratory viral agents, pleuropneumonia-like organisms, and vaccines in approximately 1,200 normal volunteers at the National Institutes of Health (NIH) Clinical Center, Bethesda, Md, an investigator told The Journal.

During the past four years, these volunteers, who are "minimum custody" inmates of 17 federal institutions, have contributed significantly to the present knowledge of virology and respiratory disease, Vernon Knight, MD, chief of the Laboratory of Clinical Investigations (LCI), said.

Through the volunteer program, LCI investigators have carried out extensive research on rhinoviruses in man, analyses of protein content of nasal secretions present in the common cold syndrome, and studies of the factors controlling resistance to that respiratory disease. Also, Knight's laboratory workers have developed a method of inoculation with virus in small particle aerosol and a method of purifying at least one type of adenovirus vaccine. (See story which follows.)

In addition to

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