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March 8, 1965

Hemolytic Uremic Syndrome

Author Affiliations

From the Department of Surgery, Section of Urology (Drs. McQuiggan and Cerny), and the departments of pediatrics (Dr. Oliver) and pathology (Dr. Littler), University of Michigan Medical Center, Ann Arbor, Mich.

JAMA. 1965;191(10):787-792. doi:10.1001/jama.1965.03080100005001

In six infants and children, acute renal failure, following diarrhea, was associated with hemolytic anemia and thrombocytopenia. This combination of findings, referred to as the hemolytic uremic syndrome, has been recognized with increasing frequency. Four of six patients died despite treatment by transfusion and dialysis. The pathological findings were not uniform and included glomerulonephritis, thrombotic thrombocytopenic purpura, and renal cortical necrosis. The etiology remains obscure. Available evidence suggests that a hypersensitivity process is involved in the pathogenesis.

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