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March 8, 1965

Plasma Renin Activity in Primary Aldosteronism

JAMA. 1965;191(10):867-868. doi:10.1001/jama.1965.03080100085037

To the Editor:—  The recent Clinical Science communications by Conn et al1 and Conn2 contain errors of both fact and interpretation, on some of which we wish to comment.Of a patient we described3-5 with hypertension, measurably low plasma renin concentration, and overproduction of aldosterone following renal artery reconstruction, Dr. Conn remarks, "in view of our results (Conn, et al, 1964), one would suggest that, at that time [1963], the diagnosis of primary aldosteronism could have been made." Our earlier statement3 that "this combination [ie, hypertension, overproduction of aldosterone, and low plasma renin] might be anticipated in patients with aldosteronism due to primary abnormalities in the adrenal glands," and the subsequent confirmation of this prediction in such cases,6,7 precludes major disagreement on this point. However, of the same patient's investigations Dr. Conn remarks, "it would seem wise to look for the [adrenal] tumor, especially when