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March 15, 1965

Experimental Therapy

Author Affiliations

Orange, NJ

JAMA. 1965;191(11):948. doi:10.1001/jama.1965.03080110072027

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To the Editor:—  I proffer the following with reference to "Experimental Therapy?" a question and answer (JAMA190:1142 [Dec 28] 1964) to which I find it necessary to invite a "second look." I believe I am correct in stating that the vital and most pertinent part of the query is the phrase in parentheses "utilizing an established drug." If therapy were to be undertaken with an established drug, the toxicity, side reactions, appropriate dosages, and contraindications would have been ascertained and published, and the prescribing doctor would (presumedly) be guided thereby in his employment thereof. If such be true, why should the respondent deem it proper to apply his fourpronged and frightening procedure to this established drug in each instance where it is prescribed. Mr. Bergen's formulation is scholarly but, in my opinion, not suited to the precise situation described in the query. If that procedure be necessary in

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