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March 22, 1965

Canine Renal Homografts: Prolongation of Homografts by Delayed Antimetabolite Administration

Author Affiliations

From the Surgical Research Laboratory, Veterans Administration Hospital, and the Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tenn.

JAMA. 1965;191(12):1017-1018. doi:10.1001/jama.1965.03080120051014

Mercaptopurine,1-3 azathioprine,4,5 and 6-methyl mercaptopurine6 prolong canine renal homograft survival when administered on the day of transplantation and thereafter. The most advantageous time to begin immunosuppressive therapy for the highest percentage of long-term survivors has not been determined. The present experiments were designed to evaluate the effect of a one, two, or three day delayed administration of these drugs on canine renal homograft survival.

Methods  Utilizing 79 female mongrel dogs weighing 10 to 15 kg, pairs of dogs underwent bilateral nephrectomy and had a renal homograft exchanged between them. The renal artery and vein were anastomed to the external iliac artery and common iliac respectively. The ureter was placed into the bladder. The immunosuppressive agents were administered orally the day of transplantation in some and one, two, and three days after homografting in the remainder. The following dose regimens were given: mercaptopurine, 5 mg/kg for four days, then