Coronary flow and hemodynamic alterations were studied in dogs, following the intravenous administration of 0.5, 1.5, and 5 gm of ethyl alcohol/kg of body weight. Alcohol in low (0.5 gm/kg) or moderate (1.5 gm/kg) dosages causes a marked increase in work load of the heart proportionate to the amount administered. After toxic dosages (5gm/kg) all animals, although protected from respiratory failure, showed rapid and progressive deterioration with rising atrial pressure, hypotension, and death due to cardiac failure. At all dosage levels, coronary flow decreases and coronary resistance rises. The total peripheral resistance remains unchanged with low dosages but falls with larger dosages of alcohol. The same responses were noted with bonded bourbon as with laboratory alcohol.
Webb WR, Degerli IU. Ethyl Alcohol and the Cardiovascular System: Effects on Coronary Blood Flow. JAMA. 1965;191(13):1055–1058. doi:10.1001/jama.1965.03080130015004
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: