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March 29, 1965

A New Oral Penicillin: Ampicillin (Penbritin, Polycillin)

JAMA. 1965;191(13):1071-1072. doi:10.1001/jama.1965.03080130031009

The antibacterial spectrum of ampicillin is similar to that of the other penicillins, except that it is more effective against some gram-negative bacteria. It is effective against enterococcic infections resistant to penicillin G, but is not effective against penicillinase-producing staphylococci. Its indications include susceptible infections of the urinary tract, respiratory tract, and soft tissues. It is also effective in the treatment and prophylaxis of exacerbations of chronic bronchitis. Ampicillin produces the allergic reactions typical of the other penicillins, and its use is contraindicated in patients who have a history of sensitivity to penicillin.