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April 19, 1965

Loeffler's Syndrome: Report of Two Cases

Author Affiliations

From the Section of Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minn.

JAMA. 1965;192(3):254-256. doi:10.1001/jama.1965.03080160074025

LOEFFLER'S SYNDROME is characterized by migrating lung infiltrates and by eosinophilia.1 The diagnosis is based on the radiographic picture and the presence of eosinophilia. The pulmonary infiltration may be unilateral or bilateral and may be located in any part of the lung. The percentage of eosinophils in the blood may range from 10% to 80%. The cause is unknown, but the disorder most likely is an allergic reaction in the lung to a foreign antigen. The course is usually benign.

Report of Cases 

Case 1.—  A 34-year-old farm wife was referred to this clinic because of unexplained fever, shortness of breath, and chest pain of three weeks' duration. Before the present illness she had been perfectly well. She was hospitalized elsewhere and treated with antibiotics for pneumonia of the left upper lobe. Ten days after the onset of the illness, the infiltrative process that had been present had progressed