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April 26, 1965


JAMA. 1965;192(4):320-321. doi:10.1001/jama.1965.03080170048013

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It is with reluctance that we publish the communication beginning on p 309. It reports the results of the topical use of dimethylsulfoxide (DMSO) in 548 patients with various musculoskeletal disorders. Physicians are cautioned to read the contribution with the following in mind: (1) DMSO is an investigational drug; its availability for general use is months to years away, pending the results of tests for the Food and Drug Administration. (2) Because of the distinctive odor of the drug, it has been impossible as yet to conduct controlled, double-blind studies. (3) The period of follow-up is too brief to indicate whether there will be delayed side effects. Because of these serious limitations it is perhaps premature to report on this drug even as a preliminary communication. The Journal feels constrained to do so, however, because of the inordinate amount of lay publicity accruing to this drug over the past 15

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