In recent years, as our knowledge about the etiology of the "common cold" has increased, man has been hopeful of finding a way to control this problem. Although it is recognized that many viral agents may cause upper-respiratory-tract infections —including the viruses of influenza and parainfluenza, respiratory syncytial virus, adenovirus, the enteroviruses, herpes simplex virus, reovirus, and the viruses of variola, varicella, rubeola, and rubella —the discovery of the rhinoviruses and their association with the common cold gave rise to the hope that control of the last-named viruses might significantly reduce the number of common colds in the adult population. Development of an experimental vaccine for echovirus 28, since shown to have the properties of a rhinovirus, together with the demonstration that vaccine-induced neutralizing antibody to this virus in volunteers provided protection against illness after challenge with this agent, offered encouragement for the ultimate development of an effective vaccine for
HAH—CHOOO! JAMA. 1965;192(4):322–323. doi:10.1001/jama.1965.03080170050016
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