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April 26, 1965

Penile Malignancy and Hypercalcemia

Author Affiliations

From the Division of Urologic Surgery, Duke University Medical Center, Durham, NC.

JAMA. 1965;192(4):328-329. doi:10.1001/jama.1965.03080170056021

THE DIFFERENTIAL diagnosis of hypercalcemia includes hyperparathyroidism, hypervitaminosis D, the milk-alkali syndrome, sarcoidosis, multiple myeloma, hyperthyroidism, acute osteoporosis, and metastatic bone disease. Recently there have been 30 sporadic case reports of hypercalcemia occurring in patients with nonparathyroid neoplasms without significant bone disease.1-4 The present report concerns the first case known to us of squamous-cell carcinoma of the penis, with hypercalcemia and without evident bone metastases; serum calcium level returned to normal within 24 hours after removal of the primary penile lesion.

Report of a Case  A 60-year-old white man was admitted May 12, 1964, with a six-month history of induration and ulceration of the glans, bilateral inguinal lymphadenopathy, decrease in size of urinary stream, burning on urination, progressive weight loss, generalized malaise, lethargy, and muscular weakness. He denied a history of polyuria, polydipsia, renal colic, renal stones, bone pain, nausea, vomiting, indigestion, constipation, dryness of the nose, dysphasia, cardiac