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April 26, 1965

Hypnotic Induction of Anxiety: A Psychoendocrine Investigation

Author Affiliations

Oklahoma City

JAMA. 1965;192(4):336. doi:10.1001/jama.1965.03080170064035

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


This compact volume presents in detail five research projects on the hypnotic induction of anxiety. Conducted by a multidisciplinary team over a five-year period, it is one of the most carefully controlled and elegantly designed research under-takings of its kind.

The investigators, who have carefully reviewed the background of research on emotions, are familiar with the advantages and limitations of hypnotic techniques and gave careful attention to the population of normal volunteers with whom they worked. Intelligent application of appropriate biostatistical methods enabled them to assess potential sources of bias in sampling, in selection of a volunteer population, and in the question of hypnotizability.

The general plan of these experiments was to induce anxiety by direct hypnotic suggestion, to study its clinical manifestations, to measure it with psychological instruments, and to delineate endocrine changes reflecting the anxiety state.

Significant effects of anxiety were found with four criteria of the Rorschach

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