A controlled study of the wound acceleration induced by fine-grind acid-pepsin digested calf tracheal cartilage has been made in 15 human volunteers. Small paired skin incisions were made in precisely corresponding anatomical sites, and one wound treated with the powder by atomization while the other wound served as the control. Closure was identical. After varying (7 to 14 days) intervals of time, the wounds were excised with a margin and the resulting defects closed. The tensile strengths of the wounds were then determined. In 12 of the 15 wound pairs, the treated wound was stronger. The overall percentage increase in tensile strength resulting from the treatment was 42%, and the difference is statistically highly significant. The effectiveness of this material in the acceleration of human wound healing is considered established.
Prudden JF, Allen J. The Clinical Acceleration of Healing With a Cartilage Preparation: A Controlled Study. JAMA. 1965;192(5):352–356. doi:10.1001/jama.1965.03080180010002
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