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May 10, 1965


JAMA. 1965;192(6):568. doi:10.1001/jama.1965.03080190134030

The appearance of a syndrome resembling systemic lupus erythematosus (SLE) during the administration of procainamide hydrochloride can no longer be considered a rare occurrence. In this issue (p 444) Kaplan and associates summarize the clinical manifestations in four new cases as well as previously reported instances of a lupuslike state associated with the use of procainamide. Since their communication was submitted for publication, an additional case1 has been described.

The first report implicating procainamide in the induction of a lupus-like state was reported in 1962. Seven instances of a lupus-like illness occurring during the administration of procainamide have been reported in the past 18 months. In one patient symptoms developed after only one month of therapy. A variety of environmental factors, including drugs, may be associated with the development of SLE. Are drugs merely precipitating factors or are they indeed capable of inducing SLE de novo? A recent study,