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May 17, 1965

A New Antibacterial Agent for Infections of the Genitourinary TractNalidixic Acid (NegGram)

JAMA. 1965;192(7):628-629. doi:10.1001/jama.1965.03080200046013

Nalidixic acid is effective in the treatment of genitourinary tract infections caused by Escherichia coli, Proteus, and other gram-negative bacteria. However, susceptible organisms may become resistant during therapy. The incidence of gastrointestinal and allergic reactions is low, but various neural disturbances have been reported occasionally.