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May 24, 1965


JAMA. 1965;192(8):711-712. doi:10.1001/jama.1965.03080210055017

Just over half a century ago the Japanese surgeon Hashimoto described the thyroid disease which now bears his name. He termed the disease "struma lymphomatosa" after observing the extensive lymphoid infiltrate in the thyroid gland. The condition has subsequently been called Hashimoto's disease, lymphadenoid goiter, lymphoid thyroiditis, and recently, auto-immunizing thyroiditis. Thyroid auto-antibodies are found in the serum of patients with the disease, and investigation of auto-immunity in Hashimoto's thyroiditis has provided information about the pathogenesis of other thyroid disorders as well. Thyroid autoantibodies are observed in patients with "primary hypothyroidism" (ie, hypothyroidism without goiter), and similar histologic findings both in this condition and in Hashimoto's thyroiditis leads to consideration whether these two disorders are manifestations of the same pathologic process.

Skillern et al1 noted the failure of the thyroid gland to respond to thyroid-stimulating hormone in both diseases and concluded that Hashimoto's thyroiditis was "primary thyroid failure with