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June 7, 1965

Penicillin Sensitivity —Continued

Author Affiliations

Portland, Ore

JAMA. 1965;192(10):920. doi:10.1001/jama.1965.03080230125032

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To the Editor:—  It is reassuring to have Dr. Cazort's concurrence in the unreliability of testing with penicilloyl-polylysine and other penicillin derivatives. Dr. Cazort has for years had vast clinical experience with this problem. A committee on penicillin allergy organized by him and now under his chairmanship will surely provide a better understanding of the entire problem.I differ with him on the advisability of testing patients who give a history of penicillin allergy. The hazard is great and should be discouraged except in highly experienced hands. A clear history of sensitivity to this drug should be sufficient for choosing another antibiotic.Before the physician tells his patient that he is clinically allergic to penicillin, the physician should be reasonably certain of the evidence. Subsequent statements from patients so informed will depend on clear clinical judgment.

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