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June 7, 1965

New Clues to a Second Genetic System

JAMA. 1965;192(10):33-34. doi:10.1001/jama.1965.03080230143051

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Furthernd growing evidence of a second genetic system and its possible role in the initiation of cancer is being reported by a woman scientist at the University of Pennsylvania.

The findings include:

  • Her report three years ago of seeing deoxyribonucleic acid (DNA) in animal cell mitochondria, an observation also made in several other laboratories.

  • Biochemical experiments, since confirmed by others, showing that the DNA was truly that of mitochondria and not nuclear contamination.

  • Systematic studies which indicate that DNA "is an integral part of most and probably all mitochondria."

  • Evidence that DNA fibers are twice to several times more concentrated in undifferentiated or rapidly dividing cells.

  • Frequent observation in ascites tumor cells of atypical DNA fibrils intimately associated with a globular body in structurally damaged mitochondria.

Husband and Wife Team  The investigator is Margit M. K. Nass, PhD, of the School of Medicine's Department

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