THE GENETIC CONTROL of the quantitative activity of a serum enzyme was first suggested by Augustinsson and Olsson with serum arylesterase (aryl ester hydrolase [International Union of Biochemistry 188.8.131.52] )1 in Swedish Landrace swine.2 However, the authors are unaware of a report of hereditary control of the quantitative activity of a serum enzyme in man although several examples of qualitative differences exist.3 These qualitative differences of the gene may result, of course, in gross changes in the quantitative activity of an enzyme as it acts upon a substrate. However, they do not express themselves as continuous quantitative changes in phenotype over a "normal" range of enzyme activity.
Such qualitative differences of serum cholinesterase (acylcholine acyl-hydrolase [IUB 184.108.40.206] )4 in man involve the "atypical" serum cholinesterase first described by Kalow,3 the C5 extra component which is most likely nonallelic with respect to the "atypical" gene5 a
Wetstone HJ, Honeyman MS, McComb RB. Genetic Control of the Quantitative Activity of a Serum Enzyme in Man. JAMA. 1965;192(11):1007–1009. doi:10.1001/jama.1965.03080240077028
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