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June 28, 1965

Exudative Pharyngitis Following Experimental Mycoplasma hominis Type 1 Infection

Author Affiliations

From the Public Health Service, National Institute of Allergy and Infectious Diseases, Laboratory of Infectious Diseases, Bethesda, Md, and the Epidemiologic Intelligence Service, Communicable Disease Center, Atlanta.

JAMA. 1965;192(13):1146-1152. doi:10.1001/jama.1965.03080260034010

It has been known for a number of years that organisms of the genus Mycoplasma can produce severe and often debilitating respiratorytract disease in birds, mice, rats, goats, sheep, and cattle.1-3 However, it was not until recently that a Mycoplasma organism was implicated in respiratory-tract disease of man.4 Recently, the Eaton agent, originally recovered in eggs in 1944, was successfully cultivated in a cell-free artificial agar medium.5-7 The organism propagated on agar medium was shown to be a Mycoplasma and was designated Mycoplasma pneumoniae.8 Previous studies had shown that this organism was the etiologic agent of cold agglutinin-positive atypical pneumonia.9,10 In addition, the agent had been associated with other milder forms of respiratorytract disease.11 In part, the role of M pneumoniae in human respiratory disease was established during a series of studies with volunteers.12,13

After the identification of the Eaton agent as a